Isaiah is a long book. That being said, it would be best to try to read through it in one sitting if possible. If not, try to set aside a set amount of time each day to read in this book. The best way to get a sense of the book is to read the whole book. A Study Bible with an outline of the book of Isaiah may be helpful to understanding the structure and themes in Isaiah. I use an NIV Study Bible (among other resources). The outline has chapters 1-39 as part 1: the book of Judgment and chapters 40-66 as Part 2, the book of comfort. In part 1, chapters 1-6 are messages of rebuke and promise. Chapter 1 is an introduction in which God levies charges against Judah for breaking the covenant. Chapters 2 through 4 deal with the future discipline and glory of Judah and Jerusalem. In chapter 2, verses 1-5 are about Jerusalem's future blessings. Chapter 2:6 through Chapter 4:1, are about The Lord's discipline of Judah. Chapter 2, verse 2, "in the last days." What does this refer to? NIV notes: "Can refer to the future generally (see Gen 49:1), but usually it seems to have in view the Messianic era. In a real sense the last days began with the first coming of Christ (see Acts 2:17; Hebrews 1:2) and will be fulfilled at his second coming." I hope this is of some help.